报告题目：Cell-based biosensors for water toxicity assessment and biomedical applications
报告人：Dr. Li Fang, Associate Professor of New York Institute of Technology
报告时间：2018年7月10日15:30
报告地点：力学系会议室（南一楼东北角E320）
邀请人：胡洪平、胡元太
Abstract: Cell-based biosensors, combined with living cells, have emerged as promising biotechnical tools in various fields. If cells are treated as the research objectives, cell-based biosensors can be used in fundamental biological research. On the other hand, cells are the sensitive elements that can sense various biophysical or biochemical signals and transduce them into changes in cell behaviours or properties that can be measured by biosensor systems. In this presentation, two studies on cell-based biosensors are introduced. One is about a multiparametric biosensor integrated with miniaturized enclosed polymeric chambers to assess water toxicity. This sensor contributes to increase the security of drinking water. The second study is about the electric cell-substrate impedance sensing (ECIS) sensor based on flexible electronics technology. ECIS electrodes were fabricated on a stretchable polydimethylsiloxane (PDMS) substrate and ECIS measurements on mammalian cells exposed to cyclic strain were performed. The stretchable ECIS biosensors simulate in vitro the dynamic environment of organism, such as pulsation, bending and stretching, which enables investigations on cell behavior that undergoes mechanical stimuli in biological tissue.
Biosketch: Dr. Li is an Associate Professor of Mechanical Engineering at New York Institute of Technology (NYIT). Her research areas are biosensors, MEMS and NEMS, Lab-on-a-chip devices, piezoelectric transducers, and non-destructive evaluations. Her research interests include micro/nano devices and stretchable electronics for biomedical applications, and wireless acoustic wave sensors for harsh environment applications.
Dr. Li has her BS and MS degrees in Precision Instruments from Tsinghua University of Beijing, China. She received her Ph.D. degree in Mechanical Engineering from the University of Pittsburgh where her doctoral research focused on bulk and surface acoustic wave sensors for monitoring cell behaviors and characterizing cell mechanical properties. She also studied how cell shape and mechanical stress affect cellular function using cell patterning techniques. After completing her doctoral studies, she worked for several years at Intelligent Automation, Inc., of Maryland, before joining NYIT’s faculty in 2012. At Intelligent Automation, Inc., she was the Principal Investigator of multiple SBIR and STTR projects funded by US ARMY, NAVY and Air Force. Her work there focused on developing portable cell-based sensor system for drinking water toxicity detection and surface acoustic microscopy system for Rapid NDE of ceramic balls. Dr. Li has published over 20 peer-reviewed journal papers and 25+ conference papers. Her research work was featured on the cover of prestigious journal “Lab-on-a-Chip” twice. She is a member of IEEE, IEEE UFFC, ASME, and SAE and has served as a reviewer for many prestigious journals.
